So I just read a new article detailing the potential interactions between PPIs and Plavix released this past July:

Norgard NB, Mathews KD, Wall GC. Drug-drug interaction between clopidogrel and the proton pump inhibitors. Ann Pharmacother. 2009;43(7):1266-1274.

It seems there is growing evidence to support that the concurrent use of PPIs and Plavix can put patients at increased risk for a recurrent cardiac event. Most trials with omeprazole show a decrease in clopidogrel effectiveness; however, there seems to be some limited evidence that pantoprazole may not be quite as bad (but nothing too convincing!).

What are your thoughts? There may be a clear role for the hospital pharmacist. Is there a role for the community pharmacist to have an impact here??

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